Migraine is a severe and difficult headache, often accompanied by sensory changes, nausea vomiting, numbness of limbs, and sensitivity to sound and light, and may persist for several hours, even a few days. The cause of migraine is unknown, but there are many factors, such as food, stress, environmental disturbances, etc. In addition, women are more likely to suffer from migraine than men, not only adults, but also migraine can occur in children. Today, research has found that in addition to these external risk factors, genes can also be One of the causes of easy migraine.
Migraine can be genetically caused
Dr. Emily A. Bates, PhD, who has suffered from migraine headaches since adolescence, and a group of members from the University of California, San Francisco (UCSF) and Brigham Young University ( Brigham Young University researchers found that specific mutations could increase a person’s chance of developing migraine.
The discovery was first published in the May 2013 Science Translational Medicine journal, where Dr. Bezie reported , shared her experience of adolescent migraine. At that time, Dr. Bates was a member of the sports team, and she always wondered when migraines would come. Migraines not only affected her practice and race performance, but also caused a lot of trouble for her work and study. Dr. Bezz decided to devote scientific research to understand the causes of migraine, potential treatments, and possible preventive measures. The journey ended up leading Dr. Bates to become a PhD in Chemistry at Brigham Young University.
Although Dr. Bezie later stopped having migraines, she continued to work on migraine and joined the University of California San Francisco Louis Ptáček gene The research team mainly observed two families with migraine genetic genes. The aim was to find out whether these two families had common genetic mutations. Results The team found that members of the two families with migraine had a mutation gene that could affect Casein kinase delta.
To confirm that this discovery was no coincidence, the team conducted animal experiments on rats, embedding mutations in white rats and stimulating them with nitroglycerin, and finally, no mutations were normal. mice, to see if this will cause migraine pain. The results found that rats with mutations are less resistant to stimulation than normal rats, that is, mutation genes can increase migraine symptoms.