Drug Facts : The main function of Adalimumab is to inactivate tumor necrosis factor-α (TNFα). For the treatment of rheumatoid arthritis, psoriatic arthritis, rigid spondylitis, Crohn’s disease, ulcerative colitis, psoriasis, purulent sweat adenitis, uveitis, and juvenile idiopathic arthritis. Imitation is recommended for subcutaneous injection in other patients with inefficacy.

How do I use Adalimumab?

Please follow your doctor’s instructions and read the medication instructions carefully and comply with them. Inject in areas where body fat is high. If you need to inject it by yourself, your doctor or nurse will explain how to inject it. Please note that hands should be washed before and after injection. Follow the instructions of your doctor or medication instructions before using this medicine.

Do not shake the drug. Do not use if it is cloudy, exposed or has particles. Do not use if the drug is not clear and colorless.

Do not inject on red and swelling area of the skin. When injecting, please inject in different areas of the skin each time. If you need to do so, remove the drug from the refrigerator 15 to 30 minutes before the injection. This medicine can be placed at room temperature without removing the packaging and lid. Do not heat this medicine.

Prepare the needle/sharpen recycling bin, discard the used needle, and comply with regulations to handle subsequent discards. Injection needles and other utensils cannot be reused. If in doubt, consult a physician or a pharmacist. Discard the syringe after use and must not be reused.

How to store Adalimumab?

Adalimumab are best kept in the refrigerator, but do not freeze in order to prevent damage to the drug. Different brands of medicines may have different storage methods, so be sure to read the drug manual or consult your pharmacist to learn how to save them. For safety, keep the medication out of reach of children and pets.

Do not flush Adalimumab into the toilet or sink unless instructed by your doctor. If the drug is expired or no longer used, dispose of it properly. Consult your pharmacist for safe disposal.

Cautions

Before taking the medicine, be sure to inform your doctor if:

If you are pregnant or are breastfeeding, pregnant or lactating women can only take the medication indicated by your doctor.
Be sure to inform your doctor if you are taking other medications. Non-prescription drugs must also be informed, such as herbal medicine, paramedical medicine, etc.
Be sure to inform your doctor if you are allergic to any of the active, inactive ingredients, or any other drug allergies.
If you have other diseases, please let your doctor know.
Please inform all of your medical authorities, including physicians, nurses, pharmacists and dentists about your use of Adalimumab.

We must first test for hepatitis B (Hepatitis B), as hepatitis B may be more severe during the administration of Adalimumab.

Be sure to inform your doctor if you are allergic to latex. It is more susceptible to infection during medication, so wash your hands and try to stay away from other sick people. It is easy to bleed during medication, so avoid injuries.

If you want to apply other vaccines, please make sure that you have the vaccine before starting your Adalimumab treatment. Consult your doctor for vaccination as Adalimumab may increase infection rates or invalidate the vaccine.

Do not apply attenuating vaccines, such as BCG against Bladder cancer, during the treatment of Adalimumab horses. Remember to consult a physician.

Please complete the blood test as instructed by your doctor. If you have sunburn or other skin problems, please contact the doctor and complete a skin test. Be sure to inform your doctor if you suddenly grow new warts, skin ulcers or swelling bleeding, wounds that cannot heal, change of colours of moles, etc.

For some people who use Adalimumab, the nervous system will react abnormally and symptoms may not be normal, so if you have abnormal burning, numbness, tingling, or vision loss, dizziness, seizures, weakness of hands and feet, be sure to see a doctor immediately.

Adalimumab can affect the purpose of other medications in your body more or less, so if you are taking other medications, consult a physician. A close blood test may be required during the course of the treatment.

Patients over 65 years of age may have more side effects, so use this drug with greater caution. If the patient is a child, caution is also required when using Adalimumab medications. Consult your doctor for more information. Be sure to inform your doctor if you are pregnant or are planning to get pregnant. Your doctor will tell you about the potential efficacy and risks of using this drug during pregnancy.

If you are pregnant when using the Adalimumab horse, be sure to inform your obstetrician or pediatrician. If you are breastfeeding, be sure to inform your doctor about the risks of the drug to your baby.

Is it safe to use Adalimumab during pregnancy or lactation?

There is not enough research on the risk of Adalimumab horses to pregnant and lactating women, so consult a physician before taking medication to weigh the potential efficacy and risk of the drug. The US Food and Drug Administration (FDA) classified Adalimumab as a pregnancy drug risk class B, details are as follows:

Class A: No danger
Class B: Some studies confirm no risk
Level C: May be at risk
Class D: proven at risk
Level X: Prohibited
Level N: Risk unknown

Potential side effects of Adalimumab horse

The following are very serious side effects. If you have the following symptoms, see a doctor immediately.

Allergic reactions such as rash, hives, itchy skin, blistering, skin decrumbling, asthma, throat card, chest tightness, dyspnea, abnormal hoarseness, or mouth, lip, tongue , swelling of the throat and face, please see a doctor immediately.

Symptoms of infection

ever, chills, sore throat, pain in the nose (or sinus), cough, sputum or discoloration, pain in urination, mouth sores, non-healing wounds, etc.
Lupus symptoms such as rose-like rash on the body or cheek, easy sunburn, muscle or joint pain, chest pain, shortness of breath, swollen hands and feet, etc.
chest tightness or chest pain.
Very severe headache.
Too tired and weak.
Severe dizziness or fainting.
Unidentified bruises or bleeding.
Night Sweats.
A sharp drop in weight.
Fever is more than just.
Swelling of the glands.
Swelling of the skin.
Blood urine.
Pale complexion.
Severe pain at the injection site.
The skin is reddish and has pustules.

Patients who have taken Adalimumab have had very serious, even fatal, liver problems. Therefore, if symptoms of liver abnormalities such as urine excretion, abnormal tiredness, feeling no hunger, stomach pain or discomfort, dull color, vomiting, and yellowing of skin or eyes, see a doctor immediately.

There are also patients who have taken Adalimumab and have developed heart failure. Those who already have heart failure problems had their condition exacerbated. So if you have a heart condition, please let your doctor know. Consult your doctor immediately if you experience shortness of breath, weight gain, arrhythmia, or swelling of your hands and feet (or if you already have these symptoms but become severe).

Not all people have these side effects, and the above does not contain all possible side effects. Therefore, if you are concerned about side effects, consult a physician or pharmacist.

Potential Interaction of Adalimumab

What drugs do Adalimumab affect?

Adalimumab may affect other medications you are taking, thus affecting the effects of these medications and increasing the risk of serious side effects. To avoid drug interaction, patients should make a list of the drugs being taken, including prescription, non-prescription, herbal, and then inform physicians and pharmacists. For safety, do not use drugs, discontinue drugs or change the dosage without the consent of a doctor.

Will food and alcohol interact with Adalimumab?

Adalimumab may interact with food and alcohol, changing the efficacy of drugs and increasing the risk of serious side effects. Consult your doctor or pharmacist before taking medication to find out what food and alcohol can affect the Adalimumab.

What kind of physical condition affects the Adalimumab?

Adalimumab can be affected by physical condition, which can lead to worse physical condition, or change the effect of drugs. Be sure to let your doctor or pharmacist know your physical condition.

Use doses of Adalimumab

The following information is not a medical diagnosis. Be sure to consult a physician or pharmacist before using Adalimumab.

What is the dose for Adalimumab?

Stiffness spondylitis General dose for adults:

40mg per time, injected into subcutaneous tissue once every 2 weeks

General for adults of rheumatoid arthritis:

40 mg per time, injected into subcutaneous tissue once every 2 weeks

General for adults of psoriasis arthritis:

40 mg per time, injected into subcutaneous tissue once every 2 weeks

General doses for adults with acute clones disease:

Initial dose: 160 mg on day 1, injecting into subcutaneous tissue; can be done in one day or divided into 2 consecutive days. Change to 80 mg after 2 weeks (day 15), the same injected into subcutaneous tissue.

Maintenance dose (after the 29th day): 40 mg per time, injected into subcutaneous tissue once every 2 weeks

General doses for adults for long-term treatment of clones’s disease:

Initial dose: 160 mg on day 1, injections in subcutaneous tissue; can be completed in 1 day or divided into 2 consecutive days. Change to 80 mg after 2 weeks (day 15), the same injected into subcutaneous tissue.

Maintenance dose (starting on day 29): 40 mg per time, injected into subcutaneous tissue once every 2 weeks

General dose for adults of ulcerative colorectal cancer:

Initial dose: 160 mg on day 1, injections in subcutaneous tissue; can be completed in 1 day or divided into 2 consecutive days. Change to 80 mg after 2 weeks (day 15), the same injected into subcutaneous tissue.

Maintenance dose (starting on day 29): 40 mg per time, injected into subcutaneous tissue once every 2 weeks

General dose of eye iritis for adults:

Initial dose: 80 mg, injected into subcutaneous tissue

Maintenance dose: starting 1 week after the first dose, 40 mg per time, injected into subcutaneous tissue once every 2 weeks

General dose for adults of plaque psoriasis:

Initial dose: 80 mg, injected into subcutaneous tissue

Maintenance dose: starting 1 week after the first dose, 40 mg per time, injected into subcutaneous tissue once every 2 weeks

General dose for adults of purulent sweat adenitis:

Initial dose: 160 mg on day 1, injections in subcutaneous tissue; can be completed in 1 day or divided into 2 consecutive days. Change to 80 mg after 2 weeks (day 15), the same injected into subcutaneous tissue.

Maintenance dose (starting on day 29): 40 mg per time, injected into subcutaneous tissue once every 2 weeks

What is the dose for children?

General dose for children with idiopaedic arthritis:

Over 2 years of age and:

10~15 kg: 10 mg per time, injected into subcutaneous tissue once every 2 weeks.
15~30 kg: 20 mg per time, injected into subcutaneous tissue once every 2 weeks.
More than 30 kg: 40 mg per time, injected into subcutaneous tissue once every 2 weeks.
General doses for children with acute clones disease:

Over 6 years old and 17-40 kg:
First dose: 80 mg on day 1, injections in subcutaneous tissue; change to 40 mg after 2 weeks (day 15), as in subcutaneous tissue
Maintenance dose: 20 mg per time, injected into subcutaneous tissue once every 2 weeks
More than 40 kg:

Initial dose: 160 mg on day 1, injections in subcutaneous tissue; can be completed in 1 day or divided into 2 consecutive days. Change to 80 mg after 2 weeks (day 15), same injection in subcutaneous tissue
Maintenance dose: 40 mg per time, injected into subcutaneous tissue 1 time every 2 weeks.
General dosage for children with long term treatment of Clone’s disease:

Over the age of 6, and: 17-40 kg:
First dose: 80 mg on day 1, injections in subcutaneous tissue; change to 40 mg after 2 weeks (day 15), as in subcutaneous tissue
Maintenance dose: 20 mg per time, injected into subcutaneous tissue 1 time every 2 weeks.
More than 40 kg:

Initial dose: 160 mg on day 1, injections in subcutaneous tissue; can be completed in 1 day or divided into 2 consecutive days. Change to 80 mg after 2 weeks (day 15), same injection in subcutaneous tissue
Maintenance dose: 40 mg per time, injected into subcutaneous tissue 1 time every 2 weeks.

Drug forms of Adalimumab?

Subcutaneous injection

What should I do if I overdose on Adalimumab or have a sudden condition?

In case of overdose or sudden condition, please visit the emergency room.

What if I miss my shot time?

If you miss the shot time, please fill up as soon as possible. But if it is close to the next scheduled injection time, discard the missed shot and proceed to only inject the latter one. Do not inject two shots at a time.

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