Drug Facts : Amoxicillin is an antibiotic like penicillin that can treat many diseases caused by bacterial infections and prevent the growth of bacteria. However, antibiotics are not suitable for infections caused by viruses (such as common colds, flu), and abuse of antibiotics can lead to bacterial resistance and reduce the effectiveness of treatment. Amoxicillin can also be used in conjunction with other drugs to treat gastro/intestinal ulcers caused by Helicobacter pylori, and to prevent recurrence of ulcers.

Other uses: Certain categories of patients with heart disease (e.g. patients with heart valvular diseases) may also use these drugs to prevent heart infection prior to medical/dental surgery.

How to use Amoxicillin

Take orally before meals on an empty stomach or after meals, as directed by your physician every 8-12 hours. The amount of the dose depends on your own physical condition and your response to treatment. Antibiotics inhibit bacterial growth best when the amount of drugs in the body remains at a certain concentration. Even if symptoms disappear a few days after taking the medicine, you need to continue taking the medicine according to the prescription until you finish your medication. Premature discontinuation of the drug may give the bacteria the chance to continue to grow and cause a recurrence of infection. Drink more water during medication unless specifically instructed by your doctor.

How to store Amoxicillin

Amoxicillin is best kept at room temperature and avoid light and moisture. To prevent damage to medicines, Amoxicillin should not be stored in the bathroom or in the refrigerator. Different brands of Amoxicillin may have different storage needs, so be sure to read the instructions for storage in the product packaging or consult your pharmacist. For safety purposes, all medicines should be kept out of reach of children and pets.

Do not flush Amoxicillin into the toilet or pour into the drainage pipe unless clearly indicated. When the drug expires or is no longer needed, it is important to dispose properly. For more information about safely disposing the drug, please ask your doctor or pharmacist.

Amoxicillin Precautions and Contraindications

Inform your physician and pharmacist about the prescription and non-prescription drugs, vitamins, supplements and herbs you are taking to prevent side effects, especially the following:Chloramphenicol, Various antibiotics、Probenecid

Before using this drug, inform your doctor of all your medical history, especially if you are or have had kidney disease, allergies, asthma, hay fever , hives or Phenylketonuria.
If you are pregnant or are breastfeeding, please inform your doctor, as only medicines recommended by your doctor should be taken during pregnancy and lactation.

Is it safe to use Amoxicillin during pregnancy or breastfeeding?

There are not enough studies that suggest that Amoxicillin is at risk to pregnant or lactating women, but consult a doctor before taking medication to measure the potential efficacy and risks of the drug.

The US Food and Drug Administration (FDA) lists Amoxicillin as a pregnancy drug risk level B.

A: No risk
B: Mild risk
C: Medium risk
D: High risk
X: Absolute prohibition
N: Unknown

Potential side effects of the use of Amoxicillin

Tell your doctor immediately if you experience the following allergic reactions:

Urticaria
Difficult breathing
Swelling of the face, lips, tongue or throat.
Not everyone will have the same side effects. Some side effects not mentioned below may also occur. If you have any doubts about side effects, consult a physician or pharmacist.

Less serious side effects:

Stomach pain, nausea, vomiting
Vaginal itching or appearance of secretions
Headache
Black tongue (swollen tongue, appearance of whole black moss)

Stop using Amoxicillin immediately and contact your doctor if any of the following serious side effects:

White plaque or ulcer in the mouth or lips
Fever, enlarged tonsils, itchy rash, joint pain or general discomfort
Pale or yellowed skin tone, yellow eyes, darker urine, fever, blurred consciousness or weakness
Severe paralysis, pain, muscle weakness
Prone to bleeding, inexplicable bleeding (nose, mouth, vagina or rectum), small purple or red spots under the skin
Severe skin reactions such as fever, sore throat, swelling of the face or tongue, burning eyes, unknown pain in the skin, plus a reddish purple rash (especially on the face or upper body), plus blisters and peeling

Potential interaction with Amoxicillin

What drugs interact with Amoxicillin?

Amoxicillin and Clavulanate may interact with other drugs you are taking, which may change the way the drug acts or increase the risk of serious side effects. To avoid all possible interactions, you should list all medications you are using (both prescription and non-prescription) and inform your physician and pharmacist. For your safety, do not start, stop, or change any dosage of the drug without the approval of your physician. Please pay special attention to the following medicines:
Acenocoumarol
Acrivastine
Bupropion
Chlortetracycline
Demeclocycline
Doxycycline
Khat
Lymecycline
Meclocycline
Methacycline
Methotrexate
Minocycline
Oxytetracycline
Probenecid
Rolitetracycline
Tetracycline
Venlafaxine
Warfarin

Does food and alcohol interact with Amoxicillin?

Food and alcohol may interact with Amoxicillin in, which can change the efficacy of the drug and increase the risk of side effects, so consult your doctor or pharmacist about food and alcohol that may affect the efficacy.

What kind of physical condition interacts with Amoxicillin?

Amoxicillin and Clavulanate may worsen your physical condition or alter the efficacy of other drugs on you. So be sure to let your doctor or pharmacist know your physical condition before taking it.
For example:
Addiction to Penicillins or other cephalosporous drugs, e.g. Cefaclar, Cefadroxil, Cephalexin, Ceftin, or Keflex
Patients with infectious mononucleosis (Mononucleosis) and other viral infections should not take amocillin.
Patients with severe kidney disease, due to poor renal function, slower metabolism, increased concentration of drugs in serum and doubled efficacy. Patients with poor renal function should reduce the dose of the drug.
Phenylketonuria (PKU) is exacerbated by its chewable tablets containing phenylalanine.

Recommended Dosage of Amoxicillin

The following information does not represent medical advice. Ask your doctor or pharmacist before taking medication.

Drug Facts Amoxicillin – Adult Doses

Actinomycosis:500 mg 3 times daily, or 875 mg twice daily. The drug lasts for 6 months.
Anthrax Prophylaxis:500 mg orally every 8 hours.
Cutaneous Bacillus anthracis:3 times daily, oral 500 mg.
Bacterial Endocarditis:1 hour before the procedure, take 2 grams orally.
Chlamydia Infection:Pregnant patients take 500 mg orally 3 times daily for 7 days as an alternative to Erythromycin.
Cystitis:3 times a day, 250 to 500 mg orally for 3 to 7 days, or 500 to 875 mg twice a day.
Urinary Tract Infection:3 times a day, 250 to 500 mg orally for 3 to 7 days, or 500 to 875 mg twice a day.
Helicobacter pylori Infection,Patients with gastric ulcer, duodenal ulcer, etc.: 2 to 3 times a day, 1 g oral for 14 days.
Lyme Disease Arthritis:3 times a day, 250 to 500 mg orally for 14 to 30 days
Lyme Disease Carditis:3 times a day, 250 to 500 mg orally for 14 to 30 days
Lyme Disease Erythema Chronicum Migrans:3 times a day, 250 to 500 mg orally for 14 to 30 days
Lyme Disease Neurologic:3 times a day, 250 to 500 mg orally for 14 to 30 days
Otitis Media:3 times a day, 250 to 500 mg orally for 10 to 14 days;Or oral 2 times daily, 500 – 875mg.
Pneumonia:If pneumonia is suspected to be caused by pneumococcal, 500 mg each time 3 times a day, or 875 mg twice a day for 7 to 10 days.
Sinusitis:Take 250-500 mg orally 3 times a day for 10-14 days; or take 500-875 mg twice a day.
Skin or Soft Tissue Infection:Take 250~500 mg orally 3 times a day for 10-14 days; or take 500~875 mg twice a day.
Upper Respiratory Tract Infection:Take 250~500 mg orally 3 times a day for 10-14 days; or take 500~875 mg twice a day.
Bronchitis:Take 250~500 mg orally 3 times a day for 10-14 days; or take 500~875 mg twice a day.
Tonsillitis/Pharyngitis:
Immediate-release:Take 250~500 mg orally 3 times a day for 10-14 days; or take 500~875 mg twice a day.
Extended-release:775 mg daily for 1 hour after meal for 10 days; used for secondary Streptococcus pyrasis infection.

Drug Facts Amoxicillin – Doses for children

Bacterial Endocarditis Prophylaxis:1 hour before surgery, oral, single dose, recommended dosage of 50 mg per kg of body weight.
Anthrax Prophylaxis:1 time every 8 hours, oral, 80 mg per kg of body weight, the doses are equally distributed in equal doses. Maximum dose: 500 mg/dose.
Cutaneous Bacillus anthracis:Take orally every 8 hours, 80 mg per kg of body weight. Maximum dose: 500 mg/dose.

Otitis Media:
4 weeks to 3 months: 1 time every 12 hours, oral, 20~30 mg per kg of body weight.
4 months ~ 12 years old: 1 time every 8 to 12 hours, oral, 20~50 mg per kg of body weight.
Patients with acute otitis medium caused by Streptococcus pneumococcus pneumoniae: 1 time every 12 hours, oral, 80 to 90 mg per kg body weight, maximum dose: 500 mg/dose.

Skin or Soft Tissue Infection:
4 weeks to 3 months: 1 time every 12 hours, oral, 20~30 mg per kg of body weight.
4 months ~ 12 years old: 1 time every 8-12 hours, oral, 20~50 mg per kilogram of body weight.
Patients with acute otitis medium caused by Streptococcus pneumococcus pneumococcus: every 12 hours, oral, 80-90 mg per kg of body weight.

Urinary Tract Infection:
4 weeks to 3 months: 1 time every 12 hours, oral, 20~30 mg per kg of body weight.
4 months to 12 years: 1 time every 8-12 hours, oral, 20~50 mg per kilogram of body weight.
Patients with acute otitis medium caused by Streptococcus pneumococcus pneumococcus: every 12 hours, oral, 80-90 mg per kg of body weight.

Pneumonia: every 8 hours, oral, 40~50 mg per kilogram of body weight.

Tonsillitis/Pharyngitis:
4 weeks to 3 months: 1 time every 12 hours, oral, 20~30 mg per kg of body weight.
4 months ~ 12 years old: every 12 hours, oral, 20~50 mg per kg of body weight.
Over 12 years of age: Immediate-release drugs: 250~500 mg per oral dose 3 times daily for 7 to 10 days; or 2 times a day, Oral 500-875 mg. Extended-release drug: 775 mg daily for 10 days for 1 hour after meal; for patients with secondary Streptococcal pyrococcal infection.

Drug forms of Amoxicillin

Oral capsules: one tablet 250 mg or one tablet 500 mg.

Overdose or sudden condition

In case of an emergency or overdose, please contact your local emergency room or visit the nearest emergency room.

Missed time to take medication

If you miss a dose of amoxicillin, please take it as soon as possible when remembered.  However, if you are close to the next scheduled medication, skip the missed time and take the following tablet that you are scheduled to take. Do not use double doses.

Read: Knowledge of Medicines – Drug Facts Clavulanate