Drug Facts – Avastin is one cancer therapies and is widely used in the treatment of certain types of brain tumors, kidney cancers, lung cancer, colorectal cancer, cervical cancer, ovarian cancer, and fallopian tube cancer. Avastin is also used to treat cancer at the endometrial site of the abdominal organs. It is often used with other cancer drugs to improve the efficacy.

How to take Avastin?

Avastin is administered through intravenous drips. The duration of the first infusion should be more than 90 minutes. If you are well tolerated with dosage 1 and there is no adverse reaction, then the dosage time of the agent can be shortened and controlled to 60 or 30 minutes. The dosage applied depends on your health, clinical reactions to past treatments, and your weight. If your weight changes, please inform your doctor. To maximize the efficacy, use the drug continuously and regularly. Do not miss any injection treatment as much as possible.

How to store Avastin?

Glass bottled Avastin comes in 2 doses, small bottles of 100 mg and 400 mg, suitable for storage at 2 to 8°C. Bottled Avastin should be avoided from direct sunlight. Do not freeze or shake. The diluted solution of Avastin can be stored for 8 hours at 2~8°C. Avastin should be stored in its original packaging until use time.

Precautions and contraindications for use in Avastin

You should inform your physician or pharmacist if you have allergies to Avastin; or you have experienced other allergies, because Avastin contains a potential Inactive ingredients that cause allergies or other problems. Please consult a pharmacist for more details.
Please inform your physician or pharmacist of your medical history before beating, especially if you have experienced: gastrointestinal ulcers, bleeding problems, post surgery or planned surgery, unhealed wounds, hypertension, kidney disease, or diabetes.
Before using the procedure, inform your doctor or dentist about the prescription, non-prescription and herbs you are taking.

Avastin may make you more susceptible to infection, or may worsen your current condition. Avoid contact with other sources of infection, such as chickenpox, measles, flu.
Do not receive vaccinations without the consent of the doctor. Avoid exposure to people who have recently received a vive vaccine, e.g. influenza vaccine inhaled through the nose.
If you have had an allergic reaction to the drug, inform your doctor immediately. Allergic reactions include: dyspnea or chest pain. The skin may be show some redness or rash, muscle tightness, nausea, or vomiting. As the inactive ingredient in Avastin, it may cause allergic reactions or cause other problems.

To reduce the chance of cuts, bruises or injuries, avoid using sharp items such as razors and nail clippers, and avoid participating in sports that require close contact.
Special care is required when applying this drug in elderly patients, who are at greater risk of side effects, such as thrombosis, impacted kidney function and urine proteins in urine.
Pregnant women may only be given when it is clearly diagnosed that the benefits of using this drug outweight the risk as the ingredients in Avastin can cause harm to the unborn fetus.
During medication and within 6 months of discontinuation of treatment, women during childbirth should have contraception. If you are pregnant or may be pregnant, notify your doctor immediately.
Avastin may secrete into breast milk. Therefore, breastfeeding is not recommended during medication. Also, after discontinuation of treatment, consult your doctor before deciding on breastfeeding.

Does it affect pregnant women or nursing mothers?

There are not enough studies that suggest that Avastin is at risk to pregnant or breastfeeding mothers, but consult a physician before taking medication to measure the potential efficacy and risk of the drug.

According to the U.S. Food and Drug Administration (FDA) classification system for pregnancy use, this drug is rated C.

A: No risk
B: Mild risk
C: Medium risk
D: High risk
X: Absolute prohibition
N: Unknown

Potential side effects of the use of Avastin

The following side effects may occur with the use of Avastin. All possible side effects are not included below. Ask your doctor or pharmacist if you have any concerns.

The following are possible side effects. If these side effects persist or worsen, contact your doctor immediately.

Dry mouth, cough, speech sound quality change.
Loss of appetite.
Diarrhea.
Vomiting.
constipation.
Oral ulcers.
Nausea, vomiting.
Headache.

If you have any of the following serious side effects, please inform your doctor immediately.

Swelling of the feet.
Sudden weight gain.
Faster Heartbeat.
Signs of infection, such as fever, persistent sore throat.
Muscle spasms, atrophy.
Jaundice.
There are signs of problems with kidney function, such as difficulty in urination.
Difficult breathing.
Face flushing.
Serious dizziness.
Trembling or chest pain.

The use of Avastin causes thrombosis, such as pulmonary embolism, stroke, heart attack, venous deep thrombosis is not high. However, if you have a history of thrombosis, vascular disease, or have difficulty moving, using this drug increases the risk of thrombosis. The use of products containing estrogen also increases your risk. If you meet any of the above, please inform your doctor before using Avastin.

Consult a doctor immediately if any of the following side effects occur.

Shortness of breath.
Pain in the chest, around the jaw, left arm.
Unexplained thieves sweat.
Unconsciousness
Sudden sense of dizziness.
Groin, calves feel pain, swelling and fever.
Sudden and severe headache.
Stuttering
A weak palsy on one side of the body.
Suddenly blurred vision.
Avastin can also cause bleeding. Some are mild bleeding, including nosebleeding, bleeding from the gums and vaginal. However, if the situation persists or worsens, please inform your doctor or pharmacist in due course. Others are serious side effects, including gastric bleeding or lung tissue bleeding. Avastin can also contribute to increased blood pressure. Therefore, you should regularly measure your blood pressure and inform your doctor as soon as you exceed your standard to help control your blood pressure with medication.

Although rare, Avastin may cause a disease called Posterior reversible encephalopathy. syndrome. Consult a doctor immediately if persistent headache, convulsions, sudden vision changes, mental and emotional changes occur. Avastin may also affect ovarian function, affecting hormones leading to reduced fertility.

Potential interaction with Avastin

What drugs interact with Avastin?

The drug that may interact with Avastin is another cancer treatment drug called Sunitinib. Avastin may also interact with other medications you are taking, changing the drug’s action or increasing the risk of serious side effects. To avoid any potential drug interaction, list all medications you are taking, including prescription, non-prescription and herbs, for the reference of physicians and pharmacists. For your own safety, do not take without permission, discontinue or adjust the dosage of the drug without instructions from your doctor.

Will food and alcohol interact with Avastin?

Avastin may interact with food or alcohol, affecting the absorption of the drug, or increasing the risk of serious side effects. Consult your physician or pharmacist for the interaction of a particular food or alcohol with this drug.

What physical condition affects Avastin

The use of Avastin in specific physical conditions may worsen the physical condition or affect the functioning of the drug. Therefore, it is important for physicians and pharmacists to fully understand their current state of health.

Recommended dosage for Avastin

The following information does not represent medical advice. Be sure to ask your doctor and pharmacist before taking medication.

Adult Doses

Injection solution

Injections should not be administered in an intravenous or rapid push of a single large dose. Can only be administered as an intravenous injection as a drip inlet. Avastin may not be given for 28 days after major surgery. You must wait until the surgical wound heals completely.

The duration of the first administration of a pharmaceutical infusion should be more than 90 minutes. Second dose and subsequent infusion: If you are well tolerated and have no adverse reaction, then the infusion time of the drug can be shortened. The second dose is more than 60 minutes, and if the tolerance is still good, the subsequent Infusion time can be controlled for more than 30 minutes. Patients should continue treatment until the disease worsens.

Metastatic Colorectal Cancer (mCRC)

When combined with chemotherapy based on intravenous 5-FU (5-fluorouracil), it is recommended to give Avastin 5 mg/kg or 10 with intravenous drip infusion mg/kg every 2 weeks.
When combined with fast-injected IFL (Bolus-IFL, IFL: Irinotecan anti-cancer rectified intravenous infusion concentrate), the recommended dose is Avastin 5 mg/kg.
When combined with FOLFOX4, a recommended dose of 10 mg/kg body weight: FOLFOX 4 is a chemotherapy drug, supported by Eloxatin injection, 5-FU and Leucovorin are composed of three drugs.

When used for the treatment of patients who have undergone therapy with Avastin, the second line of treatment is still worsened with fluoropyrimidine-irinotecan- or fluoropyrimidine-oxaliplatin-based combination of chemotherapy is recommended with intravenous drip infusion of 5 mg/kg or 10 mg// kg every 2 weeks, or 7.5 mg/kg every 3 weeks.

Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

When combined with Carboplatin and Paclitaxel, the recommended dose is 15 mg/kg intravenous infusion every 3 weeks.

Glioblastoma

The recommended dose is 10mg/kg intravenous infusion every 2 weeks.

Metastatic Renal Cell Carcinoma (mRCC)

When combined with immunotherapy interferon-α (interferon alfa, IFN-α), the recommended dose is administered for intravenous infusion of 10 mg/kg per Once 2 weeks.

Cervical Cancer

When combined with chemotherapeutic drugs paclitaxel and cisplatin (Paclitaxel and cisplatin), or paclitaxel and Topotecan) combined, the recommended dose is 15 mg/kg, administered every 3 weeks, with intravenous infusion.
Sensitive recurrent ovarian epithelial cells resistant to platinum, fallopian tubes or primary peritoneal cancer (Platinum-Sensitive Recurrent Epithelial Ovarian Cancer)
When combined with intravenous chemotherapy agents Paclitaxel, Pegylated, Liposomal doxorubicin, or Topotecan , the recommended dose is 10 mg/kg 1 times every 2 weeks. If topotecan is administered every 3 weeks, Avastin combined with it is recommended to be administered at a dose of 15 mg/kg and an intravenous infusion every 3 weeks.
Platinum-sensitive recurrent ovarian epithelial cells, fallopian tubes or primary peritoneal cancer.
The recommended dose is for intravenous infusion of 15 mg/kg (body weight) every 3 weeks.

Intravenous solution

Colorectal Cancer

When combined with IFL chemotherapy drugs Irinotecan, Fluorouracil, Leucovorin, the recommended dose is 5 mg/kg every 2 weeks Once.
When combined with FOLFOX4 chemotherapy drugs Oxaliplatin, Folinic acid, and Fluorouracil, the recommended dose is 10 mg/kg with intravenous drip every 2 weeks.
should be based with Fluoropyrimidine-irinotecan- or Fluoropyrimidine-oxaliplatin- Combined use of chemotherapy, the recommended dose is 5 mg/kg once every 2 weeks, or 7.5 mg/kg once every 3 weeks. Use continuously until the condition ceases to deteriorate.

Doses for children

The recommended dose of Avastin for use in children is still unknown. Not necessarily safe for children. Safety should be considered before administration of the drug. Consult your physician or pharmacist for further advice.

Drug forms of Avastin

Injection solution
Intravenous solution

Overdose or sudden condition

In case of overdose or sudden condition, go to the nearest emergency.

Missed time for medication

If you miss a dose of Avastin, please take it as soon as possible when remembered.  However, if you are close to the next scheduled medication, skip the missed time and take the following that you are scheduled to take. Do not take double doses.

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