Trihexyphenidyl is used for the symptomatic treatment of Parkinson’s disease in monotherapy or in combination. It is active in postencephalitic, arteriosclerotic and idiopathic forms. The drug is also commonly used to treat extrapyramidal side effects that occur during antipsychotic therapy. It reduces the frequency and duration of oculogyric crises as well as dyskinetic movements and spastic contractions. Trihexyphenidyle can improve the psychotic depression and mental inertia frequently associated with Parkinson’s disease and the symptomatic problems caused by antipsychotic treatment.

The drug cannot cure Parkinson’s disease, but can significantly relieve symptoms. It is estimated that 50 to 75% of people with Parkinson’s disease will respond positively and experience symptomatic improvement of 20 to 30%. To increase therapeutic activity, trihexyphenidyl is often administered concomitantly with levodopa, other antimuscarinic or antihistamine agents. Combination therapy with dopamine agonists such as cabergoline is also possible. This is often called a “multidimensional approach”. It has also been prescribed for essential tremors and akathisia

How to store this Trihexyphenidyl

Store the drug in a container locked and kept out of reach of small children. Store the medicine at room temperature, away from high temperatures, high humidity (not in the bathroom) and direct sunlight. Discard drugs that are expired or no longer needed. Ask the pharmacist how to properly handle this medicine if you are still unsure.

Does Trihexyphenidyl affect pregnant women or nursing mothers?

There are some studies that suggest that Trihexyphenidyl is at risk to pregnant or breastfeeding mothers, but consult a physician before taking medication to measure the potential efficacy and risk of the drug.

According to the U.S. Food and Drug Administration (FDA) classification system for pregnancy use, this drug is rated C.

A: No risk
B: Mild risk
C: Medium risk
D: High risk
X: Absolute prohibition
N: Unknown

What are the special things I should pay attention to when taking Trihexyphenidyl?

The following information does not represent medical advice. Be sure to ask your doctor and pharmacist before taking medication.


Chlorpromazine, Haloperidol and Perphenazine possible interaction.

Before taking this drug

  • Please tell your physician or pharmacist if you have an allergic reaction to Trihexyphenidyl or other medications
  • Tell your doctor or pharmacist about the medications you are taking (including non-prescription drugs), especially, Symmetrel, Digoxin, Haldol, Larodopa, Sinemet, tranquilizers and vitamins. 3.
  • Tell your doctor or pharmacist about your current or previous illnesses, such as kidney or liver disease,Myasthenia gravis, problems with heart or blood pressure, problems with the urinary system, prostate glands or stomach.
  • You must know that this medicine can cause drowsiness before you are aware of the possible effects of the drug on you. So, do not drive or use dangerous machinery.
    alcohol will exacerbate the lethargy effect caused by this medicine.
  • Do not drink alcohol during taking this medicine.

Potential side effects of the use of Trihexyphenidyl

Although the side effects caused by Trihexyphenidy are not common, they can still occur. Please notify your doctor as soon as possible if the following symptoms occur or still persist:

  • Drowsiness
  • Dizziness or blurred vision
  • Dry mouth
  • Gastrointestinal discomfort
  • Vomiting
  • Diarrhea
  • Constipation
  • Increased eye awareness
  • Light sensitivity
  • Difficulty in urination.

Inform your doctor immediately if you have any of the following symptoms:

  • Skin rash
  • Fast heartbeat
  • Irregular or palpitations
  • Fever
  • Confusion
  • Depression
  • Illusions or hallucinations
  • Eye pain.

How do I take Trihexyphenidyl?

Trihexyphenidyl is an oral tablet, liquid or long-lasting capsule, which is usually taken three or four times a day (can be taken with food) and a long-lasting capsule once a day (taken after breakfast) ) or twice (every 12 hours), do not bite the tablets, do not open long lasting capsules, should be swallowed directly.

Follow your doctor’s instructions and ask your doctor or pharmacist if you have any questions about this medicine. The treatment of Parkinson’s disease requires long-term use, but the treatment of other conditions Trihexyphenidyl requires only a short period of time.

Do not adjust the dose or increase the number of doses without medical instructions. Sudden discontinuation may relapse symptoms of Parkinson’s disease.

What other information should I know?

To check up regularly, your doctor may help you with some tests to determine your reaction to Trihexyphenidy. Don’t let anyone take your medication. Ask the pharmacist any questions about drug reconditioning.

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