Primary Biliary Cirrhosis – Causes and Symptoms: Liver secreted bile has an important role in digestion of fats in food and in metabolism of used red blood cells, cholesterol, drugs and toxins. Primary biliary cirrhosis (PBC), mainly Biliary tract in the liver Autoimmune system attacks gradually destroyed the disease.

When the biliary tract is damaged, harmful substances accumulate in the liver because they cannot be metabolized. Sometimes, they can cause kyticular fibrosis of liver tissue and gradually form Cirrhosis. Please note that the liver tissue cannot be cured if it is injured.

How common is Primary Biliary Cirrhosis

Patients with primary biliary cirrhosis are distributed across all ages, reducing the risk factor to reduce the risk. If you have concerns about this disease, please discuss with your doctor for further information.

Symptoms of Primary Biliary Cirrhosis

Although some patients have been diagnosed with primary biliary cirrhosis, there have been no symptoms for many years, some have shown multiple symptoms.

Common early symptoms include:

  • Fatigue
  • itchy skin
  • Dry eyes and mouth

Late symptoms include:

  • Pain in the right upper abdomen.
  • Pain in bones, muscles or joints (Musculoskeletal).
  • Jaundice.
  • Hyperpigmentation: A dull complexion that is not caused by the sun.
  • Edema: Edema of legs and ankles.
  • Ascites: ascites caused by liver failure.
  • Lipoma occurs in the eyes, eyelids or palms, soles of the feet, or fat accumulates in wrinkles on the elbows or knees.
  • Osteoporosis: May cause fractures.
    elevated cholesterol.
  • Steatorrhea: Diarrhea, with greasy excreta.
  • Hypothyroidism: hypothyroidism.

The symptoms listed above do not cover all possible symptoms. If you have any questions about the symptoms, consult a doctor.

When should you go to a doctor?

If you experience any of the above symptoms or have any doubts about your health, please consult your doctor. Physical conditions vary from person to person. Symptoms and treatment are different. It’s best to discuss with your doctor and choose the treatment that is best for you.

Causes of Primary Biliary Cirrhosis

The cause of primary biliary cirrhosis is unknown. Most experts consider primary biliary cirrhosis to be an autoimmune disease; this is due to abnormal immune response in the human body, causing normal cells to be subjected to The phenomenon of attack.

Risk factors for Primary Biliary Cirrhosis

There are many risk factors for primary biliary cirrhosis, including:

  • Gender: Good hair for women.
  • Age: Good hair age group between 30 to 60 years old.
  • Genetic Factor: Family history increases your chances of infection.

Research results show that genetic factors combined with environmental factors are more likely to trigger primary biliary cirrhosis. These environmental factors include:

  • Inflammation may be caused by Bacterial, Fungal or Parasitic infection
  • Smoking.
  • Environmental toxins: Studies have shown that toxic chemicals in the environment can also induce primary biliary cirrhosis.

Diagnosis and treatment of Primary Biliary Cirrhosis

The following information is not a substitute for a medical diagnosis. Be sure to consult your doctor for more details.

How to diagnose primary biliary cirrhosis

Your doctor will ask you about your health and family history before you have a physical examination. and follow the following test procedures to diagnose:

Laboratory Examination:

Blood test for liver function index

Liver function tests is the liver index in the blood. When the cells of the liver liver or bile ducts are damaged, the indices will rise. Based on the increase in the index, it is possible to determine the condition of cell destruction.

Blood sampling for signs of autoimmune disease

The main test item is anti-mitochondrial. Anti-mitochondrial antibody, AMA, may only appear in people with autoimmune diseases. Therefore, AMA positive is a reliable indicator of autoimmune disease. However, a small number of patients with primary biliary cirrhosis have negative AMA.



High frequency sound waves are used to produce images of internal organs of the body.

Computerized tomography (also known as CT scan)

CT scan utilizes special X-ray technology to provide a more detailed message.

Magnetic resonance imaging (MRI)

MRI scanners use magnetic fields and radio waves to provide internal organs and Detailed images of the organization. MRI does not involve radiation irradiation, unlike CT.

Magnetic resonance elastography (MRE)

This is a newer technology that uses MRI imaging combined with sound waves. Visual images of organs in the body (Elastogram, also known as Elastogram, can be used to examine different levels of cirrhosis (liver fibrosis), similar to palpate by physician Examine the body.


With the help of X-ray, it is an invasive method of examination that can lead to complications. As MRI technology advances, doctors are less and less using bile duct photography for diagnosis.

If the diagnosis is still in doubt, the doctor will perform a liver biopsy. A liver biopsy is taken out and sent to the laboratory as a sample to confirm the degree of diagnosis or disease. Since this condition is irreversible, medical technology cannot cure it today. Treatment focuses on slowing down the progression of the disease, alleviating symptoms and preventing complications. These treatment options include:

Ursodeoxycholic acid (UDCA)

UDCA, also known as Actigall, Urso, is a bile acid that helps bile through the liver. UDCA is treated as the first line of treatment and does not cure primary biliary cirrhosis, but may prolong the patient’s life if used early in the disease. UDCA is not effective for all patients, better for early patients and limited for end-stage patients.

Liver transplantation

When patients face liver failure, liver transplantation becomes a priority for treatment. Liver transplantation is a procedure that transforms a donor’s healthy liver into a patient’s body to replace a debilitated liver. Most of the donations come from decaders, while in a few cases a small portion of the living liver is taken from the living person. Primary biliary cirrhosis may also relapse several years after transplantation.

The treatment recommended by your physician focuses on the control of symptoms that make your life more comfortable, often with the control of the most common symptoms.

How to treat Primary Biliary Cirrhosis

Portal hypertension

Since your initial diagnosis and subsequent years, your doctor will monitor venous hypertension and dilatation. In the event of portal hypertension or bleeding, the treatment regimen may include drugs such as B blockers or nitrate. Or need surgery.


Your doctor will recommend adding calcium and vitamin D supplements, as well as exercising more to increase bone density.

Vitamin deficiency

Your doctor may recommend supplementation of vitamins A, D, E, and K. Consult your doctor before taking herbal or nutritional supplements.

Life adjustment and home therapy for Primary Biliary Cirrhosis

The following lifestyle and home remedies may help you improve primary biliary cirrhosis

  • Low sodium food: choose low sodium or non-sodium natural food. Sodium can cause body tissue water and swelling, abdominal cavity water.
  • Multi exercise: to strengthen bones and reduce bone loss.
  • Avoid drinking alcohol: alcohol is metabolized by the liver, the stress caused by the liver can cause liver damage. Patients should quit alcohol.
  • Consult your doctor before taking herbs or nutritional supplements. Liver sickness may be more sensitive to prescription, non-prescription, or dietary supplements, resulting in different reactions than previous ones.

If you have any questions, consult your doctor for the best treatment.

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